What is the xhxh genotype Shows?
Xhxh Genotype Shows: If an X chromosome carrying a normal gene for Factor VIII is XH, an X carrying the abnormal or hemophilic gene is Xh. Then the different possibilities for clinical status (phenotype) and genetic makeup (genotype). Genotype refers to genes in our DNA that are responsible for a specific trait. Organisms with even a slight gene difference are said to have different genotypes.
An xhxh genotype is the entire genetic constitution of an individual, i.e., the genetic makeup of an organism or group of organisms concerning a single trait, set of traits, or an entire complex of traits. In a nutshell: your genotype is your complete heritable genetic identity, the sum of genes transmitted from parent to offspring.
The mutation is a spontaneous and random change of genetic material, namely the cell’s DNA in an organism. A mutagen is a substance that causes transformation or increases the mutation rate to a dangerous level. Mutation occurs spontaneously in natural conditions. A new genetic material produced by conversion is called a mutant. A mutant can exist as a mutant gene, mutant cell, mutant organelle, or mutant individual.
X-linked traits are influenced by alleles found on the X chromosome. X-linked alleles require a specific notation: Xc or X+ where the “+” represents the dominant allele and the lowercase letter the recessive allele. Females will have two X-linked alleles (because females are XX), whereas males will only have one X-linked allele (because males are XY). The majority of human X-linked characteristics are recessive.
Implications of xhxh genotype on human health.
In many genes, different variants (genotypes) alter the expressed outcomes (phenotype) even when exposed to the same environmental exposure. When health outcomes differ by genotype and require one or more ecological stimuli, the health outcome is said to result from gene-environment interaction.
Some gene variants can be beneficial, protecting against the harmful effects of outside agents. Today, it is understood that complex interactions between environmental exposures and genetic variations contribute to the risk of developing prevalent chronic diseases like cancer, Parkinson’s disease, and diabetes.
SNPs also have implications for evolutionary biology, so GWAS can help identify forms of genetic variation that underlie phenotypic differences between healthy individuals. Understanding this normal genetic variation across different populations allows us to know how other groups have evolved and diverged and may have implications for protecting species against future environmental challenges.
Frequently asked questions
An xhxh genotype is the entire genetic constitution of an individual, i.e., the genetic makeup of an organism or group of organisms concerning a single trait, set of traits, or an entire complex of features.
A female carrier of hemophilia x A male
Male Genotype is XY
Carrier female; heterozygous, Hemophilia is sex-linked and caused by a recessive allele.
Genotypic sex refers specifically to an individual’s two sex chromosomes. The majority of people either have an X and a Y chromosome (genotypic male) or two X chromosomes (genotypic female).
A female with hemophilia would have to have her 2 sex chromosomes (the two X’s), or pair 23, with the hemophilia alleles. These alleles can’t be the dominant or “normal” allele, (are called ‘H’).
Since this is a recessive disorder, one XH allele will give a normal phenotype. When the offspring do not have an XH and solely possess the Xh allele or alleles, they will be hemophilic. Man’s genotype is XhY.
If the baby gets the Y chromosome from the father, it will be a boy. If the boy gets his mother’s X chromosome with the hemophilia gene, he will have hemophilia. He will have typical blood coagulation if he receives his mother’s other X chromosome. If the baby gets the X chromosome from the father, it will be a girl.